The study used antibiotic resistance in E. coli blood culture samples patients Shahid Sadoughi hospital in 2015

Document Type : Original article

Authors

1 Msc of Medical Microbiology, Department of Medical Microbiology Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Msc of Medical Parasitology & Mycology, Department of Medical Parasitology & Mycology Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Msc of Medical Parasitology & Mycology, Department of Medical Parasitology & Mycology Medical Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Introduction: E. coli is one of important causes of illness in children, elderly and people with weakened immune systems in the developing countries This Bacterial Agent several illness such as sepsis, UTIs, meningitis, gastroenteritis. The most prevalent gram-negative bacilli isolated from the patients with sepsis. The purpose of this study was to evaluate the antibiotic resistance of Escherichia coli blood culture sample used in hospital patients Shahid Sadoughi Yazd to achieve rapid and appropriate treatment information for patients.
 
Methods : This cross-sectional study was conducted in 2015 in Yazd hospital Shahid Sadoughi. Between 6429 blood samples were evaluated by bacteriological tests of 104 samples were infected with bacteria E. coli .The antibiotic resistance E. coli strains were assessed disk diffusion method and then the data were analyzed by software spss18.
Results: Among the samples that were obtained in 104 patients (%1/67) and Escherichia coli by testing for microbiological and chemical isolated and then from 9 antibiotics that were used gentamicin (GM) %1/34 and meropenem (MEN) %2/69, the lowest resistance and the highest resistance ceftriaxone (CRO) %20/62 and Cefixime (CFM) %22/42.
Conclusion: According to a study was conducted antibiotics in the treatment of disease caused by the E. coli, which can be used have been successfully meropenem (MEN) and gentamicin (GM)

Keywords

References

1.Alizadeh TP, Navabi B, Shariat M. Neonatal urinary tract infection: clinical response to empirical therapy versus in vitro susceptibility at Bahrami Children’s Hospital-Neonatal Ward: 2001-2010. Acta medica Iranica. 2011;50(5):348-52.[in Persian].
2. Heidari-soureshjani E, Heidari M, Doosti A. Epidemiology of urinary tract infection and antibiotic resistance pattern of E. coli in patients referred to Imam Ali hospital in Farokhshahr, Chaharmahal va Bakhtiari, Iran. Journal of Shahrekord University of Medical Sciences. 2013;15(2):915.[in Persian].
3. Clermont O, Bonacorsi S, Bingen E. Rapid and simple determination of theEscherichia coli phylogenetic group. Applied and environmental microbiology. 2000;66(10):4555-8.
4. Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. The Lancet infectious diseases. 2010;10(9):597-602.
5. Mojtabaei S, Noorsalehi E. Survey on Efficacy of Antibiotics in Gram Negative Septicemia in Neonates and Children. Journal of Guilan University of Medical Sciences. 2004;13(50):32-44.[in Persian].
6. Cederbaum SD, Niwayama G, Stiehm ER, Neerhout RC, Ammann AJ, Berman W. Combined immunodeficiency presenting as the Letterer-Siwe syndrome. The Journal of pediatrics. 1974;85(4):466-71.
7. Khani B. B-Poster Presentation. Iranian Journal of Reproductive Medicie. 2008;6(1):33.[in Persian.[
8. Hugonnet S, Sax H, Eggimann P, Chevrolet J-C, Pittet D. Nosocomial bloodstream infection and clinical sepsis. Emerging infectious diseases. 2004;10(1):76.
9. Tabatabaei S. Frequency and antimicrobial susceptibility of bacteria isolated from Urine, stool, and blood cultures of Rafsanjan University of Medical Sciences Laboratories during 2003. Journal of Rafsanjan University of Medical Sciences. 2008;7(2):105-12.[in Persian].
10. Moradi N, Javadpoor S, Vahdani M. Prevalence and antibiogram pattern of gram negative bacteria isolated from blood cultures in shahid mohammadi hospital, Bandar Abbas. Journal of Preventive Medicine. 2015;2(2):0-.[in Persian].
11. Sáenz Y, Briñas L, Domínguez E, Ruiz J, Zarazaga M, Vila J, et al. Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins. Antimicrobial agents and chemotherapy. 2004;48(10):39964001.
12. Jan N, Meshram SU, Kulkarni A. Plasmid profile analysis of multidrug resistant E. coli isolated from UTI patients of Nagpur City, India. Romanian Biotechnological Letters. 2009;14(5):463540.
13. NOVÁKOVÁ I, KAČÁNIOVÁ M, Haščík P, PAVLIČOVÁ S, Hleba L. The resistance to antibiotics in strains of E. coli and Enterococcus sp. isolated from rectal swabs of lambs and calves. Scientific Papers Animal Science and Biotechnologies. 2009;42(2):322-6.
14. Maleki A, Ebrahimian S, Omranii M, Ranjbar A, Mikaeili A. Evaluation of Blood Culture of Neonatas Suspected Septicaemia in Hazrate Masoomeh Hospital of kermanshah, Iran (2006). Medical Laboratory Journal. 2009;3(1):0-.[in Persian].
15. Schiappa DA, Hayden MK, Matushek MG, Hashemi FN, Sullivan J, Smith KY, et al. Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: a case-control and molecular epidemiologic investigation. Journal of Infectious Diseases. 1996;174(3):529-36.
16. Kang C-I, Kim S-H, Park WB, Lee K-D, Kim H-B, Kim E-C, et al. Bloodstream infections due to extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for mortality and treatment outcome, with special emphasis on antimicrobial therapy. Antimicrobial agents and chemotherapy. 2004;48(12):4574-81.
17. Kim Y-K, Pai H, Lee H-J, Park S-E, Choi E-H, Kim J, et al. Bloodstream infections by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome. Antimicrobial agents and chemotherapy. 2002;46(5):1481-91.

Files

Share

How to cite

Statistics