The effect of Elaeagnus angustifolia on women's sexual function: A systematic review

Document Type : Review Article

Authors

1 Assistant professor in Reproductive Health, Nursing & Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant Professor, pediatric nursing, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 MSc of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran

4 Master of Epidemiology, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background and Aims: sexual performance is considered part of a woman's sexual health. Elaeagnus angustifolia is a well-known source of flavonoids. Therefore, the current study was conducted with the aim of determining the effects of elderflower on women's sexual performance by evaluating and summarizing the results of the trials conducted in a systematic review.
Materials and methods: In this study, a systematic review was conducted to search for articles in Persian and English databases using the keywords sexual desire, sexual function, sexual satisfaction, aromatherapy, elderflower, orgasm, dyspareunia, aromatherapy, complementary medicine, and clinical trials. And all the possible combinations of these words were evaluated with Boolean operators OR, AND in the period from 2000 to August 2023. The evaluation of the quality of the articles was done by the Jadad scale.
Results: Out of the final 4 studies, 3 studies examined sexual satisfaction, 2 studies examined sexual desire, 1 study examined orgasm, and 1 study examined dyspareunia. The duration of elder flower extract in the intervention group was 4 weeks in one study and 35 days in 3 studies. The method of using elderflower was inhalation and oral.
Conclusion: In general, the results of this systematic review show the positive effect of consuming 4.5 grams of elder flower in the form of 4 capsules per day (2 capsules every 12 hours) or by inhaling 4-5 drops of elder flower essence 20 minutes before intercourse. It affects the sexual performance of women aged 18-40 for 4-5 weeks.

Keywords


 

1.       Yeniel A, Petri E. Pregnancy, childbirth, and sexual function: perceptions and facts. International urogynecology journal. 2014;25(1):5-14.
2.       Karimian Z, Atoof F, Azin SA, Maasoumi R, Khoei EM. Sexual behaviors and its predictors among Iranian women living in Kashan city 2017: a cross-sectional study. International journal of fertility & sterility. 2018;12(3):207.
3.       Johnsdotter S. The impact of migration on attitudes to female genital cutting and experiences of sexual dysfunction among migrant women with FGC. Current sexual health reports. 2018;10(1):18-24.
4.       Khalili M, Mirzazadeh A, Chegeni M, Abedi L, Rajaei L, Ardalan G, et al. Prevalence of high-risk sexual behavior among Iranian young people: A systematic review and meta-analysis. Children and Youth Services Review. 2020:105526.
5.      Valizadeh F, Mohammadbeigi A, Chaman R, Kashefi F, Nazari AM, Motaghi Z. Sexual and Reproductive Health Challenges in Temporary Marriage: A Systematic Review. Journal of Research in Health Sciences. 2021;21(1).
6.       Xiao Z, Mehrotra P, Zimmerman R. Sexual revolution in China: implications for Chinese women and society. AIDS care. 2011;23(sup1):105-12.
7.      Muhamad R, Horey D, Liamputtong P, Low WY, Sidi H. Meanings of sexuality: views from Malay women with sexual dysfunction. Archives of sexual behavior. 2019;48(3):935-47.
8.       Belkin ZR, Krapf JM, Goldstein AT. Drugs in early clinical development for the treatment of female sexual dysfunction. Expert opinion on investigational drugs. 2015;24(2):159-67.
9.       Goldstein I, Clayton AH, Goldstein AT, Kim NN, Kingsberg SA. Textbook of female sexual function and dysfunction: Diagnosis and treatment: John Wiley & Sons; 2018.
10.     West SL, Vinikoor LC, Zolnoun D. A systematic review of the literature on female sexual dysfunction prevalence and predictors. Annual review of sex research. 2004;15(1):40-172.
11.     Bozorgi M, Memariani Z, Mobli M, Salehi Surmaghi MH, Shams-Ardekani MR, Rahimi R. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. The Scientific World Journal. 2013;2013.
12.     Malviya N, Jain S, Gupta VB, Vyas S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction-a review. Acta Pol Pharm.;68(1):3-28. 201
13.     Jiang F, Xie J, Dan J, Liu J, Wang H. Selection of optimal ultrasonic extraction process of Elaeagnus angustifolia L. by uniform design. Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials. 2001;24(12):891-2.
14.     Ito TY, Polan ML, Whipple B, Trant AS. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. Journal of sex & marital therapy. 2006;32(5):369-78.
15.     Khare R. Globalizing South Asian Food Cultures. Curried Cultures: Globalization, Food, and South Asia. 2012;34:237.
16.     Gupta M, Nath R, Srivastava N, Shanker K, Kishor K, Bhargava K. Anti-inflammatory and antipyretic activities of β-sitosterol. Planta medica. 1980;39(06):157-63.
17.     Khalaj A. The Effect of Hydroalcoholic Extract of Elaeagnus angustifolia Flower on Serum Level of Estrogen and Progesterone in Mature Female Rats. Qom University of Medical Sciences Journal. 2018;11(11):41-8.
18.     Zeinalzadeh S, Mohagheghzadeh AA, Ahmadinezhad F, Akbarzadeh M. Comparison of the effect of Elaeagnus angustifolia flower capsule and sildenafil citrate tablet female sexual interest/arousal disorder in clinical trial study. Journal of family medicine and primary care. 2019;8(11):3614.
19.    Akbarzadeh M, Zeinalzadeh S, Zolghadri J, Mohagheghzadeh A, Faridi P, Sayadi M. Comparison of Elaeagnus angustifolia extract and sildenafil citrate on female orgasmic disorders: a randomized clinical trial. Journal of reproduction & infertility. 2014;15(4):190.
20.     Sanaz Z, Dabbaghmanesh Mohammad H, Marzieh A, Ali MA, Mehrab S. Investigation of the effect of Elaeagnus angustifolia flower capsule on sexual satisfaction and levels of androgenic hormones in 18-40 year old married women with low sexual desire referring to selected clinics of Shiraz University of medical sciences. 2017; 28 (17): 7443-7450
21.     Jafari B, Babazadeh R, Salari R, Jamali J, Sadeghi T. The effect of Elaeagnus angustifolia flower essence inhalation on dyspareunia and sexual satisfaction of women at reproductive age: A randomized clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2021 Jun 22;24(4):56-67.
22.     Emaminia F, Rezaei A, Badehnoosh B, Ramezani R, Shabani M. The effects of Elaeagnus angustifolia L. whole fruit on the sex hormone profile in menopausal women: A double-blind, randomized, placebo-controlled study. Journal of Ethnopharmacology. 2020;246:112229.
23.     Moher D, Altman DG, Liberati A, Tetzlaff J. PRISMA statement. Epidemiology. 2011;22(1):128.
24.     Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? 1996;17(1):1-12.
25.     Farzaei MH, Bahramsoltani R, Abbasabadi Z, Rahimi R. A comprehensive review on phytochemical and pharmacological aspects of Elaeagnus angustifolia L. Journal of Pharmacy and Pharmacolo .67(11):1467-80.2015
26.     Hosseinzadeh H, Ramezani M, Namjo N. Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice. Journal of ethnopharmacology. 2003;84(2-3):275-8.
27.     Hanna KL, O'Neill S, Lyons-Wall PM. Intake of isoflavone and lignan phytoestrogens and associated demographic and lifestyle factors in older Australian women. Asia Pacific journal of clinical nutrition. 2010;19(4):540-9.
28.     Azarnioushan F, Khatamsaz S, SADEGHI HE. The effects of hydro alcoholic extract of Dorema Aucheri on blood concentration of gonadotropin and androgen hormones in adult male rats. 2009.
29.    Kang DG, Choi DH, Lee JK, Lee YJ, Moon MK, Yang SN, et al. Endothelial NO/cGMP-dependent vascular relaxation of cornuside isolated from the fruit of Cornus officinalis. Planta medica. 2007;73(14):1436-40.
30.     Giuliano F, Rampin O, Allard J. Neurophysiology and pharmacology of female genital sexual response. Journal of sex & marital therapy. 2002;28(sup1):101-21.
31.     Basson R. Women's sexual dysfunction: revised and expanded definitions. Cmaj. 2005;172(10):1327-33.
32.     Malakouti J, Farshbaf Khalili A, Asghari Jafarabadi M, Jabbari F. Effect of combined inhaler aromatherapy on sexual function in postmenopausal women: a randomized controlled trial. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2016;19(1.2):9-15.
33.     Ali B, Al-Wabel NA, Shams S, Ahamad A, Khan SA, Anwar F. Essential oils used in aromatherapy: A systemic review. Asian Pacific Journal of Tropical Biomedicine. 2015;5(8):601-11.
34.     Niazi A, Moradi M. Sexual satisfaction and function in postmenopausal women treated with herbal medicines: a review of clinical trials. Evidence Based Care. 2019;9(2):7-16.