A review Dental pulp stem cells: isolation, identification and applications in regenerative medicine

Document Type : Review Article

Authors

1 -Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran -Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 - Student Density, Student Research Committee, Faculty of Density, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background and Aims: Stem cells, possessing the capacity for self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming impediments to Regenerative Potential. The ease of isolation of Dental pulp stem cells (DPSCs) from discarded or removed teeth offer a promising source of autologous. This review briefly highlights the Specification of DPSCs and then focuses on DPSCs applications across the scope of regenerative medicine.
Materials and Methods: The present study was a review study. By using keywords Consumer Organizations Consumerism, dental pulp, regenerative medicine, mesenchymal stem cells, tissue regeneration, Articles were extracted without time limit from Web of Science, PubMed, Google Scholar, SID, Magiran databases. The inclusion criteria included studies that were in line with the research objective.
Results: DPSCs derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors suitable for regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured tissue. These unique properties, together with their ready accessibility, have made DPSCs an attractive and practical cell source for use in tissue engineering and regenerative medicine.
Conclusion: The properties mentioned above could suggest that DPSCs are an ideal stem cell resource for therapeutic approaches to tissue repair and regeneration in diseases. However, the need for more clinical studies seems necessary.

Keywords

References

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Navid No
Volume 26, Issue 88
February 2024
Pages 40-67

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