Epidemiological factors of co-infection with Human Immunodeficiency Virus and tuberculosis, patients referred to the Infectious Behavioral Diseases Center of Mashhad

Document Type : Original article

Authors

1 1. Assistant Professor, Department Infectious disease, School of Medicine, Mashhad medical science, Islamic Azad university, Mashhad, Iran

2 دکترای حرفه ای پزشکی، دانشکده پزشکی، علوم پزشکی مشهد، دانشگاه آزاد اسلامی ، مشهد، ایران

3 Department of Nursing, Faculty of Nursing and Midwifery, Mashhad Medical Science, Islamic Azad University, Mashhad, Iran.

4 Department of Nursing, Faculty of Nursing and Midwifery, Mashhad Medical Science, Islamic Azad University, Mashhad ,Iran.

Abstract

Background & Objectives: The global spread of tuberculosis is due to the AIDS epidemic to the extent that it is considered a serious health threat, especially for people infected with HIV. Therefore, this study was conducted with the aim of investigating the epidemiological factors of simultaneous infection of AIDS and tuberculosis in patients with AIDS referred to Mashhad Center for Infectious Behavioral Diseases.
Methods: In this cross-sectional descriptive study, 103 patients with AIDS who were referred to Mashhad Center for Infectious Behavioral Diseases between 2012 and 2019 were examined. In this research, the required information, including age, gender, occupation, marital status, nationality, prison history, addiction, was collected using a researcher-made questionnaire. SPSS software (version 23.0) was used for data analysis. P-value less than 0.05 was considered statistically significant.
Results: from103 patients with AIDS, 14 cases (13.6%) had simultaneous tuberculosis, 9 men (8.7%), 5 women (4.9%). The frequency of tuberculosis was significantly higher in the group of workers, people with prison history and family history of tuberculosis (P < 0.05).
Conclusion: Most of the patients with AIDS and TB in Mashhad are men, young people aged 29 to 49, workers, people with a history of prison and addiction. The results of the present study indicate the need for accessible and effective health and medical services to reduce current infections and prevent new infections in the population.

Keywords

References

1.      Alemu A, Wubie Aycheh M, Dilnessa T. Tuberculosis and Human Immunodeficiency Virus Co-Infection and Associated Factors at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia: A Four-Year Retrospective Study. HIV/AIDS-Research and Palliative Care. 2021:293-9.
2.      de Oliveira Sena IV, Flôr SMC, Júnior FWD, de Araújo MB, Viana RR, Almeida PD. Clinical-epidemiological study of TB-HIV coinfection in priority municipality: 10 years análisis. Enfermería Global. 2020;19(4):109-19.
3.      dos Santos AC, de Abreu Aquino RC. Perfil epidemiológico de pacientes imunocomprometidos com tuberculose. Revista Eletrônica da Estácio Recife. 2019;5(1).
4.      CDC. TB and HIV Coinfection. https://wwwcdcgov/. 2016.
5.      WHO. Global Tuberculosis Report Geneva: World Health Organization. 2021;https://www.who.int/health-topics/tuberculosis#tab=tab_1.
6.      Tesfaye B, Alebel A, Gebrie A, Zegeye A, Tesema C, Kassie B. The twin epidemics: Prevalence of TB/HIV co-infection and its associated factors in Ethiopia; A systematic review and meta-analysis. PloS one. 2018;13(10):e0203986.
7.      Nyasulu PS, Ngasama E, Tamuzi JL, Sigwadhi LN, Ozougwu LU, Nhandara RB, et al. Effect of HIV status and antiretroviral treatment on treatment outcomes of tuberculosis patients in a rural primary healthcare clinic in South Africa. Plos one. 2022;17(10):e0274549.
8.      Geremew D, Melku M, Endalamaw A, Woldu B, Fasil A, Negash M, et al. Tuberculosis and its association with CD4+ T cell count among adult HIV positive patients in Ethiopian settings: a systematic review and meta-analysis. BMC infectious diseases. 2020;20:1-10.
9.      Gupta RK, Lawn SD, Bekker L-G, Caldwell J, Kaplan R, Wood R. Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa. The international journal of tuberculosis and lung disease. 2013;17(8):1014-22.
10.    Kesari SP, Basnett B, Chettri A. Spectrum of Tuberculous Infection in Patients Suffering from HIV/AIDS and Its Correlation with CD-4 Counts: A Retrospective Study from Sikkim. Indian Journal of Otolaryngology and Head & Neck Surgery. 2019;71:167-71.
11.    Nakata K, Rom WN, Honda Y, Condos R, Kanegasaki S, Cao Y, et al. Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication in the lung. American journal of respiratory and critical care medicine. 1997;155(3):996-1003.
12.    Chen CY, Huang D, Wang RC, Shen L, Zeng G, Yao S, et al. A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS pathogens. 2009;5(4):e1000392.
13.    Kazerani M, ABEDI F. Epidemiological factors of co-infection with HIV and tuberculosis, patients referred to the Infectious Behavioral Diseases Center of Mashhad. 2021.
14.    Ghate M, Deshpande S, Tripathy S, Nene M, Gedam P, Godbole S, et al. Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts. International Journal of Infectious Diseases. 2009;13(1):e1-e8.
15.    Daryazadeh S, Kuhpayehzadeh J. Prevalence of simultaneous infections and causes of death of positive-HIV
patients in incubation and AIDS phases. Razi Journal of Medical Sciences. 2016;22(139):46-55. [in persian]
16.    Santos LFS, Carneiro PHV, de Oliveira Serra MAA, Dos Santos LH, de Andrade HLP, Pascoal LM, et al. Tuberculosis/HIV co-infection in Northeastern Brazil: Prevalence trends, spatial distribution, and associated factors. The Journal of Infection in Developing Countries. 2022;16(09):1490-9.
17.    Gelaw B, Tigabu A, Tadesse T, Tegegne Z, Hailu W, Mahmud E, et al. HIV Co-Infection Among Presumptive Tuberculosis Cases and Asthmatic Patients at University of Gondar Hospital, Northwest Ethiopia. Clinical Laboratory. 2021;67(1).
18.    Hadadi A, Rasoolinejad M, Davoudi S, Nikdel M, Rasteh M. Clinical characteristics of pulmonary tuberculosis in patients with HIV/AIDS: a case-control study. Tehran University Medical Journal TUMS Publications. 2006;64(5):87-95.
19.    Mohamad Nejad E, Jalal Manesh S, Mahmudi M. Frequency of tuberculosis in patients with HIV infection with frequent visits. Journal of Health and Care. 2010;12(1):1-8. [in persian].
Navid No
Volume 26, Issue 88
February 2024
Pages 14-23

Files

Share

How to cite

Statistics