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2-Substituent Synthesis of 5-3- Methoxyphenyl and 5-4- Methoxyphenyl-1, 3, 4-Oxadiazoles, 2-Yl-Pyridine- 2-Yl-Methanol in Positions of 2 and 3 of 1, 3, 4-Oxadiazoles Containing Halogen and the Evaluation of Their Antibacterial Properties

Document Type : Original article

Authors
Yasin Sarveahrabi 1
Ali Souldozi 2
Reza Talebi 3
1 PhD Student of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran
2 Associate Professor, Faculty of Basic Sciences, Islamic Azad University, Urmia Branch, Iran
3 Assistant Professor, Faculty of Basic Sciences, Islamic Azad University, Urmia Branch, Iran
10.22038/nnj.2019.42560.1175
Abstract
Introduction: The emergence of drug resistance in microorganisms poses a serious threat to human health; therefore, new oxadiazole derivatives can be a good alternative. In this regard, the present study aimed to evaluate the antibacterial activity of the synthesized oxadiazole derivatives and compare it with conventional antibacterial drugs.
Materials and Methods: In the current study, following the one-step reaction process, new derivatives of oxadiazoles were obtained with the 1, 3, 4-oxadiazole isomer. Thereafter, they were confirmed by InfraRed )IR), Nuclear Magnetic Resonance)C-NMR), and Hydrogen Nuclear Magnetic Resonance)  H-NMR spectroscopy). Antibacterial activity of derivatives was established by performing a test and re-test on Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli. using disc diffusion method, determination of Minimum Inhibitory Concentration (MIC) and  Minimum Bactericidal Concentration (MBC) at a concentration of 1 mg/ml.
Results: As evidenced by the obtained results, the compounds synthesized at 1 mg/ml had antibacterial effects on Staphylococcus aureus and Staphylococcus epidermidis. However, they exerted no effect on the other bacteria which were tested.   
Conclusion: The results of the current study indicated that the new single-step oxadiazole derivatives have a very good antibacterial activity against Gram-positive bacteria.
Keywords
Antibacterial activity
Oxadiazole
Staphylococcus aureus
Staphylococcus epidermidis
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Navid No
Volume 22, Issue 72
Winter 2020
Pages 1-13